IND125

  Cat. No.:  DC11997  
Chemical Structure
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More than 5000 active chemicals with high quality for research!
Field of application
A novel brain penetrant antiprion compound with EC50 of 57 nM, prevents both PrP(Sc) accumulation and astrocytic gliosis in the cerebrum.
Cas No.:
Chemical Name: N-(4-(oxazol-5-yl)phenyl)-4-(3-phenylisoxazol-5-yl)thiazol-2-amine
Synonyms: IND-125;IND125
SMILES: S1C=C(C2ON=C(C3=CC=CC=C3)C=2)N=C1NC1=CC=C(C2OC=NC=2)C=C1
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A novel brain penetrant antiprion compound with EC50 of 57 nM, prevents both PrP(Sc) accumulation and astrocytic gliosis in the cerebrum; prolongs the lives of mice expressing a chimeric human/mouse PrP transgene inoculated with Creutzfeldt-Jakob disease prions.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC11997 IND125 A novel brain penetrant antiprion compound with EC50 of 57 nM, prevents both PrP(Sc) accumulation and astrocytic gliosis in the cerebrum.
DC11998 IND-114338 A novel antiprion compound with EC50 of 68 nM, significantly increases monoglycosylated/diglycosylated PrPSc..
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