SOMG-833|SOMG 833;SOMG833

Cas No.:	1268264-10-3
Chemical Name:	3-(4-methylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7-(trifluoromethyl) quinoline
Synonyms:	SOMG 833;SOMG833
SMILES:	N1C2C(=C(NCC3=CC=CC([N+]([O-])=O)=C3)C=C(C(F)(F)F)C=2)C=C(N2CCN(C)CC2)C=1
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM; displays >10,000-fold selectivity over panel of 20 kinases, including c-MET family member RON and highly homologous kinase AXL; significantly inhibits c-MET phosphorylation and the proliferation of c-MET-dependent EBC-1, MKN-45, SNU-5, and BaF3/TPR-MET cell lines with IC50 of 0.160-0.457 uM, through G1/S cell cycle arrest; demonstrates remarkable antitumor efficacy in vivo.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC46949	Terevalefim	Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor.
DC46948	Gemnelatinib	Gemnelatinib is a tyrosine kinase inhibitor (WO2018077227, implementation example 1). Gemnelatinib can be used for the research of cancer.
DC46947	Fosgonimeton	Fosgonimeton is a hepatocyte growth factor receptor agonist (WO2017210489).
DC44838	Norleual	Norleual is an angiotensin IV analog. Norleual is a highly potent HGF/c-MET inhibitor (IC50=3 pM). Norleual inhibits HGF-induced MDCK cell proliferation and invasion in vitro. Norleual also is an AT4 receptor antagonist; disrupts LTP stabilization. Antiangiogenic.
DC39099	Ningetinib	Ningetinib is a potent, orally bioavailable inhibitor of tyrosine kinase with IC50 of 6.7 nM, 1.9 nM and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. Ningetinib exhibits antitumor activity.
DC28340	BPI-9016M	BPI-9016M is a potent, orally active, and selective dual c-Met and AXL tyrosine kinases inhibitor. BPI-9016M suppresses tumor cell growth, migration and invasion of lung adenocarcinoma.
DC8515	BMS-2	BMS-2 is a potent MET kinase inhibitor with an IC50 value of 1.8nM. It also possesses potent inhibitory activity against Flt-3 and VEGFR-2 kinases, IC50 values of 4nM and 27nM respectively.
DC12007	SOMG-833	A potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM.