| Cas No.: | 72596-74-8 |
| Chemical Name: | 6H-6-imino-(2,3,4,5-tetrahydropyrimido)[1,2-c]-[1,3]benzothiazine |
| Synonyms: | PD404182;PD-404182 |
| SMILES: | N=C1SC2=CC=CC=C2C3=NCCCN13 |
| Formula: | C11H11N3S |
| M.Wt: | 217.29 |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC50 of 9 μM. PD 404182 exhibits antiangiogenic and antiviral activity in vitro[1][2]. |
| In Vitro: | PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs[1]. PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity[1]. PD 404182 inhibits HIV-1 in seminal plasma, with an IC50 of 1 μM[2]. PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD4+ T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora[2]. Cell Viability Assay[1] Cell Line: Human dermal microvascular endothelial cells (ECs) Concentration: 10-300 μM Incubation Time: 24 hours Result: Did not induce cytotoxicity. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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| 2018-0101 |
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