Crebinostat|CAS 1092061-61-4|DC Chemicals

Cas No.:	1092061-61-4
Chemical Name:	Heptanoic acid,7-(hydroxyamino)-7-oxo-,2-([1,1'-biphenyl]-4-ylmethylene)hydrazide
SMILES:	O=C(NO)CCCCCC(N/N=C/C1=CC=C(C2=CC=CC=C2)C=C1)=O
Formula:	C₂₀H₂₃N₃O₃
M.Wt:	353.422
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Fass DM, et al. Neuropharmacology. 2013 Jan;64:81-96. 2. Ghosh B, et al. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1265-71.

Description:

Crebinostat is a novel cognitive enhancer that inhibits class I HDAC/1/2/3 (IC50=0.7/1.0/2.0 nM), class IIb HDAC6 (IC50=9.3 nM) with weaker inhibition of the class I HDAC8 and no significant inhibition of the class IIa HDAC/4/5/7/9; potently induces acetylation of both histone H3 and histone H4 as well as enhanced the expression of the CREB target gene Egr1 in cultured mouse primary neurons; upregulates Bdnf and Grn, and downregulates Mapt (tau) gene expression-genes; brain penetrant.

References:

1. Fass DM, et al. Neuropharmacology. 2013 Jan;64:81-96. 2. Ghosh B, et al. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1265-71.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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