A-800141|A800141|CAS 681245-85-2|DC Chemicals

Cas No.:	681245-85-2
Chemical Name:	(Z)-2-((2-(3-(diethylamino)prop-1-en-1-yl)phenyl)sulfonamido)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid
Synonyms:	A800141
Formula:	C₂₄H₃₀N₂O₄S
M.Wt:	442.574
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A-800141 is a potent, highly specific, orally bioavailable MetAP2 inhibitor with IC50 of 12 nM, shows no inhibition for MetAP1 (IC50>30 uM); also shows a greater selectivity against other aminopeptidases, as well as a CEREP panel of >80 receptors; causes the formation of GAPDH variants with an unprocessed N-terminal methionine in cell cultures in vitro, exhibits an antiangiogenesis effect and a broad anticancer activity in a variety of tumor xenografts including B cell lymphoma, neuroblastoma, and prostate and colon carcinomas, either as a single agent or in combination with cytotoxic agents; blocks tumor growth and MetAP2 activity in mouse models, which are causally connected to MetAP2 inhibition in vivo.

MSDS

COA

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2018-0101

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