| Cas No.: | 2349307-32-8 |
| Chemical Name: | IC-8 |
| Synonyms: | 1,1',1'',1'''-((piperazine-1,4-diylbis(propane-3,1-diyl))bis(azanetriyl))tetrakis(tetradecan-2-ol) |
| SMILES: | OC(CCCCCCCCCCCC)CN(CC(CCCCCCCCCCCC)O)CCCN1CCN(CCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)CC1 |
| Formula: | C66H136N4O4 |
| M.Wt: | 1049.8 |
| Purity: | >95% |
| Publication: | 1. Fan, N., Chen, K., Zhu, R., et al. Manganese-coordinated mRNA vaccines with enhanced mRNA expression and immunogenicity induce robust immune responses against SARS-CoV-2 variants. Sci. Adv. 8(51), eabq3500 (2022). 2. Huang, C., Duan, X., Wang, J., et al. Lipid nanoparticle delivery system for mRNA encoding B7H3-redirected bispecific antibody displays potent antitumor effects on malignant tumors. Adv. Sci. (Weinh) |
| Description: | IC8 is an ionizable cationic lipid. It has been used in combination with other lipids for the formation of lipid nanoparticles (LNPs). Immunization with severe acute respiratory coronavirus 2 (SARS-CoV-2) spike glycoprotein mRNA in IC8- and manganese-containing LNPs induces IgG responses to SARS-CoV-2 Delta and Omicron variants in mice.1 Administration of mRNA encoding B7-H3 X CD3 bispecific T cell engaging (BiTE) antibodies in IC8-containing LNPs reduces tumor growth in MV4-11 and A375 mouse xenograft models. |
| References: | 1. Fan, N., Chen, K., Zhu, R., et al. Manganese-coordinated mRNA vaccines with enhanced mRNA expression and immunogenicity induce robust immune responses against SARS-CoV-2 variants. Sci. Adv. 8(51), eabq3500 (2022). 2. Huang, C., Duan, X., Wang, J., et al. Lipid nanoparticle delivery system for mRNA encoding B7H3-redirected bispecific antibody displays potent antitumor effects on malignant tumors. Adv. Sci. (Weinh) |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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