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ML349

  Cat. No.:  DC21321   Featured
Chemical Structure
890819-86-0
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More than 5000 active chemicals with high quality for research!
Field of application
A potent, specific acyl protein thioesterase 2 (APT-2, LYPLA2) inhibitor with IC50 of 144 nM and Ki of 120 nM, >20-fold selectivity over APT-1 and serine hydrolase enzyme family.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 890819-86-0
Chemical Name: (5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone
Synonyms: ML-349;ML 349
SMILES: COC1C=CC(N2CCN(C(=O)C3SC4C5=C(S(=O)(=O)CC=4C=3)C=CC=C5)CC2)=CC=1
Formula: C23H22N2O4S2
M.Wt: 454.56
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: ML349 is a potent and specific acyl protein thioesterase 2 (APT-2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM.
In Vitro: ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis of >10000 and 120±20 nM, respectively[1]. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectivley[2]. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells[3].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
2018-0101
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