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VU 0465350

  Cat. No.:  DC21807   Featured
Chemical Structure
1414843-61-0
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More than 5000 active chemicals with high quality for research!
Field of application
VU 0465350 is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM; shows no activity for ALK2/4/5, also shows affinity for TGFBR2, VEGFR2 and AMPK; blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1414843-61-0
Chemical Name: 7-(4-isopropoxyphenyl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridine
Synonyms: VU0465350;VU5350;VU 5350;VU 0465350;VU0465350;VU-0465350
SMILES: C12=NC=C(C3=CNN=C3)N1C=CC(C1=CC=C(OC(C)C)C=C1)=C2
Formula: C19H18N4O
M.Wt: 318.38
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58.
Description: A potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM; shows no activity for ALK2/4/5, also shows affinity for TGFBR2, VEGFR2 and AMPK; blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy.
References: References 1. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58. View Related Products by Target TGF beta Receptor (TGFBR)
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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