AMXT-1501 tetrahydrochloride|AMXT1501;AMXT 1501

Cas No.:	2444815-84-1
Chemical Name:	N-(5-amino-6-((3-((4-((3-aminopropyl)amino)butyl)amino)propyl)amino)-6-oxohexyl)palmitamide tetrahydrochloride salt
Synonyms:	AMXT-1501 tetrahydrochloride\|AMXT1501;AMXT 1501
Formula:	C₃₂H₇₂Cl₄N₆O₂
M.Wt:	714.768
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AMXT-1501 tetrahydrochloride (AMXT 1501, AMXT1501) is a novel potent polyamine transport inhibitor, synergistically reduces cell viability in NB cells in combination with DFMO; completely blocked radiolabeled spermidine uptake in multiple NB cell lines, whereas the combination of AMXT 1501 and DFMO was synergistic in reducing colony formation in BE(2)-C and KELLY cells; The combination treatment resulted in hypophosphorylation of retinoblastoma protein (Rb), suggesting growth inhibition via G1 cell cycle arrest in NB cells; inhibits polyamine synthesis and uptake, reduces tumor progression and prolongs survival in mouse models of neuroblastoma combined with DFMO.Solid TumorsPhase 1 Clinical

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