3M-011| CAS 642473-62-9| TLR7/8 agonist |DC Chemicals

Cas No.:	642473-62-9
Chemical Name:	N-(1-(4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-yl)methanesulfonamide
Synonyms:	3M011;3M 854A
SMILES:	CS(=O)(NC(C)(C)CN1C(COCC)=NC2=C1C3=CC=CC=C3N=C2N)=O
Formula:	C₁₈H₂₅N₅O₃S
M.Wt:	391.49
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Martinson JA, et al. Cell Immunol. 2007 Nov-Dec;250(1-2):75-84. 2. Hammerbeck DM, et al. Antiviral Res. 2007 Jan;73(1):1-11.

Description:

A potent TLR7/8 agonist and cytokine inducer; stimulates type I interferon (IFN) and other cytokines such as TNF-alpha, IL-12, and IFN-gamma from rat peripheral blood mononuclear cells; induces IL-12 and COX-2 expression in mDC from HIV+ and HIV- individuals, and inhibits H3N2 influenza viral replication in the nasal cavity; potentiates NK cytotoxicity, and shows antitumor effects in scid/B6 mice and scid/NOD mice.

References:

References 1. Martinson JA, et al. Cell Immunol. 2007 Nov-Dec;250(1-2):75-84. 2. Hammerbeck DM, et al. Antiviral Res. 2007 Jan;73(1):1-11. View Related Products by Target Toll-like Receptor (TLR)

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101

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