Rhosin hydrochloride| CAS 1281870-42-5|DC Chemicals

Cas No.:	1281870-42-5
Chemical Name:	D-Tryptophan, 2-(6-quinoxalinylmethylene)hydrazide, hydrochloride (1:1)
Synonyms:	G04 hydrochloride
SMILES:	O=C(C(CC1C2C=CC=CC=2NC=1)N)NN=CC1C=C2C(N=CC=N2)=CC=1.[H]Cl
Formula:	C₂₀H₁₉ClN₆O
M.Wt:	394.8575
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Shang X, et al. Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chem Biol. 2012 Jun 22;19(6):699-710. [2]. Shang X, et al. Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60.

Description:

Rhosin (G04) is a potent, specific RhoA subfamily Rho GTPases inhibitor that specifically binds to RhoA to inhibit GEF reaction of RhoA with Kd of 0.4 uM, does not interact with Cdc42 or Rac1, nor the LARG; specifically inhibits GEF activation of RhoA in vitro and in cells and can potently suppress breast cancer cell proliferation and invasion and induce neurite outgrowth in PC12 cells; strongly inhibits RhoA-GTP formation in NIH 3T3 cells (EC50=10-30 uM), reduces RhoA and p-MLC1 activities of MCF7 cell-derived mammospheres (EC50=30-50 uM); suppresses invasion of mammary epithelial cells, induces neurite outgrowth of PC12 cells in synergy with NGF.

References:

[1]. Shang X, et al. Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chem Biol. 2012 Jun 22;19(6):699-710. [2]. Shang X, et al. Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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