Diarylpropionitrile| CAS 1428-67-7

Cas No.:	1428-67-7
Chemical Name:	DPN
Synonyms:	Benzenepropanenitrile,4-hydroxy-a-(4-hydroxyphenyl)-;2,3-BIS(4-HYDROXYPHENYL)-PROPIONITRILE;2,3-Bis(4-hydroxyphenyl)propionitrile;Diarylpropionitrile;DPN;2,3-bis(4-hydroxyphenyl)propanenitrile;DPN Diarylpropionitrile SC-4473;SC-4473;2,3-Bis(p-hydroxyphenyl)propionitrile;propionitrile,2,3-bis(p-hydroxyphenyl);2,3-Bis(4-hydroxyphenyl)propiononitrile;2,3-Bis-(4-hydroxy-phenyl)-propionitrile;DPN compound;2,3-Bis(p-hydroxyphenyl)-propionitrile;Propionitrile, 2,3-bis(p-hydroxyphenyl);Propionitrile, 2,3-bis(p-hydroxyphenyl)-;GTPL2825;HMS3678M03;HMS3414M03;HMS;2,3-bis(p-hydroxyphenyl)propionitrile;2,3-Bis(4-hydroxyphenyl)propanenitrile;CHEMBL334773;C15H13NO2;BRD-A27143604-001-01-2;SR-01000597601-2;1428-67-7;UNII-52XWB8Q4V8;2,3-bis(4-hydroxyphenyl)-propionitrile;AS-76308;D89075;SR-01000597601-1;AMF0011;BENZENEPROPANENITRILE, 4-HYDROXY-.ALPHA.-(4-HYDROXYPHENYL)-;2,3-bis(4-hydroxyphenyl)propionitrile;AKOS022488638;2,3-Bis(4-hydroxyphenyl)propionitrile, >=98% (HPLC);Q25100751;CHEBI:63949;4-HYDROXY-.ALPHA.-(4-HYDROXYPHENYL)BENZENEPROPANENITRILE;DTXSID0040387;52XWB8Q4V8;HMS3650I14;(+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile;HMS3267P04;HB2489;BDBM50106635;CS-3514;J-007709;SR-01000597601;diarylpropionitrile;B4385;NS00134106;HY-12452;MFCD01695412;SCHEMBL1940848
SMILES:	O([H])C1C([H])=C([H])C(=C([H])C=1[H])C([H])(C#N)C([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])O[H]
Formula:	C₁₅H₁₃NO₂
M.Wt:	239.2692
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Diarylpropionitrile (DPN) is a non-steroidal estrogen receptor β(ERβ) selective ligand, demonstrates the neuroprotective effects against 10 0M Aβ1-42-induced oxidative stress and inflammation in primary rat cortical cell culture; (1-100 nM) significantly decreases neuronal cell death by increasing cell viability through a significant attenuation in the reactive oxygen species level, downregulation of pro-apoptotic activated caspase-3 and Bax, and upregulation of anti-apoptotic Bcl-2; decreases the expression levels of IL-1β and IL-6; inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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