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Bax inhibitor peptide V5

  Cat. No.:  DC23206   Featured
Chemical Structure
579492-81-2
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More than 5000 active chemicals with high quality for research!
Field of application
A cell-permeable synthetic peptide inhibitor of Bax conformational change and mitochondrial translocation.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 579492-81-2
Chemical Name: L-Lysine, L-valyl-L-prolyl-L-methionyl-L-leucyl-
Synonyms: Val-Pro-Met-Leu-Lys;BIP-V5
SMILES: O=C([C@H](CCC1)N1C([C@@H](N)C(C)C)=O)N[C@@H](CCSC)C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CCCCN)=O)=O
Formula: C27H50N6O6S
M.Wt: 586.7875
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor, used for cancer treatment.
In Vivo: V5 (100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model[2].
In Vitro: Bax inhibitor peptide V5 (0-50 μM) reduces cell death in STF-cMyc cells but not in SW620 or NCI-H23 cells. BIPV5 does not result in any significant effect on cell cycle arrest at the G2/M phase[1]. V5 treatment upregulates expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB-p65 by 10, 30, and nearly 50%, respectively[2].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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