GSA-10| CAS 300833-95-8|DC Chemicals

Cas No.:	300833-95-8
Chemical Name:	GSA 10
Synonyms:	GSA 10;propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate;4-[[(1-Hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-benzoic acid propyl ester
SMILES:	CCCCCCN1C2=CC=CC=C2C(=C(C(=O)NC3=CC=C(C=C3)C(=O)OCCC)C1=O)O
Formula:	C₂₆H₃₀N₂O₅
M.Wt:	450.526807308197
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. Eur J Med Chem. 2016;121:747-757. [2]. Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened [published correction appears in Mol Pharmacol. 2013 Aug;84(2):303]. Mol Pharmacol. 2013;83(5):1020-1029.

Description:

GSA-10 is a novel small-molecule positive modulator of Smoothened with EC50 of 1.2 uM in the differentiation assay; promotes the differentiation of multipotent mesenchymal progenitor cells into osteoblasts, this effect on cell differentiation is inhibited by Smo antagonists, such as MRT-83, SANT-1, LDE225, and M25 in the nanomolar range; binds to a novel Smo active site, and belongs to a new class of Smo agonists.

References:

[1]. Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. Eur J Med Chem. 2016;121:747-757. [2]. Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened [published correction appears in Mol Pharmacol. 2013 Aug;84(2):303]. Mol Pharmacol. 2013;83(5):1020-1029.

MSDS

COA

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2018-0101

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