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Remdesivir O-desphosphate acetonide impurity

  Cat. No.:  DC40993   Featured
Chemical Structure
1191237-80-5
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Field of application
Remdesivir O-desphosphate acetonide impurity is an impurity of Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity and is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1191237-80-5
Chemical Name: (3Ar,4R,6R,6aR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyl-6,6a-dihydro-3aH-furo[3,4-d][1,3]dioxole-4-carbonitrile
Synonyms: (3Ar,4R,6R,6aR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyl-6,6a-dih;IJCOKJGMVJGKBB-CGEWXTDFSA-N;(3aR,4R,6R,6aR)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
SMILES: O1[C@]([H])(C([H])([H])O[H])[C@]2([H])[C@]([H])([C@]1(C#N)C1=C([H])C([H])=C3C(N([H])[H])=NC([H])=NN13)OC(C([H])([H])[H])(C([H])([H])[H])O2
Formula: C15H17N5O4
M.Wt: 331.326582670212
Purity: >98%
Sotrage: Powder-20°C 3 years4°C2 yearsIn solvent-80°C6 months-20°C1 month
Description: Remdesivir O-desphosphate acetonide impurity is an impurity of Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity and is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2].
In Vitro: Remdesivir O-desphosphate acetonide impurity (analogue 21) is a 2′,3′-acetonide protected analogue of Remdesivir[1].
References: [1]. Dustin Siegel, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem. 2017 Mar 9;60(5):1648-1661. [2]. Manli Wang, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.
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