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HIF-2α-IN-4

  Cat. No.:  DC47980   Featured
Chemical Structure
882268-69-1
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More than 5000 active chemicals with high quality for research!
Field of application
HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 882268-69-1
Chemical Name: HIF-2α-IN-4
Synonyms: HIF-2a Translation Inhibitor 76;HIF-2a translation inhibitor;HIF-2α-IN-4;Methyl 3-[[cyano(methylsulfonyl)methylene]hydrazinyl]-2-thiophenecarboxylate (ACI);HIF-2;882268-69-1;Methyl 3-(([cyano(methanesulfonyl)methylidene]amino)amino)thiophene-2-carboxylate;SR-01000635592-1;HY-136748;HIF-2alpha-IN-4;SCHEMBL781448;CCG-45847;MS-24103;A-IN-4;CS-0133535;methyl 3-[(2E)-2-[cyano(methylsulfonyl)methylidene]hydrazinyl]thiophene-2-carboxylate;DA-64162;methyl 3-(2-(cyano(methylsulfonyl)methylene)hydrazineyl)thiophene-2-carboxylate;HMS554D20
SMILES: N#CC(S(C)(=O)=O)=NNC1=C(C(OC)=O)SC=C1
Formula: C9H9N3O4S2
M.Wt: 287.315459012985
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_31860_DC47980_882268-69-1
COA
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Cat. No. Product name Field of application
DC47980 HIF-2α-IN-4 HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing.
DC41030 1,4-DPCA ethyl ester 1,4-DPCA ethyl ester is the ethyl ester of 1,4-DPCA and can inhibit factor inhibiting HIF (FIH).
DC10436 SYP-5 SYP-5 is a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis.
DC9811 PT2399 PT2399(PT=2399) is a novel HIF2α Antagonist.
DC11782 IDF-11774 IDF-11774 is a novel hypoxia-inducible factor α (HIFα)-1 inhibitor with an IC50 of 3.65 μM.
DC11607 JTZ-951(Enarodustat) A novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.
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