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GUN30820

  Cat. No.:  DC60089   Featured
Chemical Structure
2104030-82-0
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Field of application
GUN30820, also known as Brr2 inhibitor C9 or Brr2 Inhibitor 9, is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa a group of progressive retinal degenerative disorders. GUN30820 was first described in Journal of Medicinal Chemistry (2017), 60(13), 5759-5771. This product has not formal name. For the convenience of scientific communication, we named it by combining its Inchi key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2104030-82-0
Chemical Name: 6-Benzyl-3-[3-(1,3-thiazol-5-ylmethoxy)phenyl]-4,6-dihydropyrido[4,3-d]pyrimidine-2,7(1H,3H)-dione
Synonyms: Brr2 Inhibitor C9;6-Benzyl-3-(3-(thiazol-5-ylmethoxy)phenyl)-3,4-dihydropyrido[4,3-d]pyrimidine-2,7(1H,6H)-dione;6-Benzyl-3-[3-(1,3-thiazol-5-ylmethoxy)phenyl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dione;6-Benzyl-3-[3-(1,3-thiazol-5-ylmethoxy)phenyl]-4,6-dihydropyrido[4,3-d]pyrimidine-2,7(1H,3H)-dione
SMILES: S1C([H])=NC([H])=C1C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])N1C(N([H])C2=C([H])C(N(C([H])([H])C3C([H])=C([H])C([H])=C([H])C=3[H])C([H])=C2C1([H])[H])=O)=O
Formula: C24H20N4O3S
M.Wt: 444.505603790283
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: GUN30820 is a potent and selective Brr2 helicase allosteric Inhibitor. Brr2-IN-3 inhibits helicase activity in dose-dependent manner with an IC50 value of 1.3 μM[1].
Target: IC50: 1.3 μM (Brr2)[1]
References: [1]. Iwatani-Yoshihara M, et al. Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. J Med Chem. 2017;60(13):5759-5771.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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