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GalNac-L96

  Cat. No.:  DC65565   Featured
Chemical Structure
1159408-62-4
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More than 5000 active chemicals with high quality for research!
Field of application
GalNac-L96, the G-rich oligonucleotides carrying the longer GalNAc linker that can be used for delivery of nucleic acid drugs[1].
Cas No.: 1159408-62-4
Chemical Name: Butanedioic acid, 1-[(3R,5S)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[1,12,19,25-tetraoxo-14,14-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-29-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-16-oxa-13,20,24-triazanonacos-1-yl]-3-pyrrolidinyl] ester, compd. with N,N-diethylethanamine (1:1)
SMILES: C(C1C=CC=CC=1)(C1C=CC(OC)=CC=1)(C1C=CC(OC)=CC=1)OC[C@@H]1C[C@@H](OC(=O)CCC(=O)O)CN1C(=O)CCCCCCCCCCC(=O)NC(COCCC(=O)NCCCNC(=O)CCCCO[C@@H]1O[C@H](COC(=O)C)[C@H](OC(=O)C)[C@H](OC(=O)C)[C@H]1NC(=O)C)(COCCC(=O)NCCCNC(=O)CCCCO[C@@H]1O[C@H](COC(=O)C)[C@H](OC(=O)C)[C@H](OC(=O)C)[C@H]1NC(=O)C)COCCC(=O)NCCCNC(=O)CCCCO[C@@H]1O[C@H](COC(=O)C)[C@H](OC(=O)C)[C@H](OC(=O)C)[C@H]1NC(=O)C.CCN(CC)CC
Formula: C127H194N12O45
M.Wt: 2608.95270013809
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Anna Clua, et al. Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. Molecules. 2022 Jun 20;27(12):3944.
Description: GalNac-L96,富含 G 的寡核苷酸,带有较长的 GalNAc 连接子,可用于递送核酸药物。
References: [1]. Anna Clua, et al. Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. Molecules. 2022 Jun 20;27(12):3944.
MSDS
Cat. No. Product name Field of application
DC67296 Galnac GLS-15 GLS-15 is a novel GalNAc-derived small molecule structure designed for siRNA delivery.
DC66575 Peracetylated GalNAc PEG linker-Acid-2
DC66574 Peracetylated GalNAc-L96-1
DC66572 Peracetylated GalNAc PEG linker-Amino-2
DC66569 GalNAc-L96-Amide
DC66568 Peracetylated GalNAc PEG linker-Amino-1
DC66565 Peracetylated GalNAc-L96-Acid-1
DC66564 Peracetylated GalNAc PEG linker-Acid-1
DC66561 Peracetylated GalNAc succinimidyl pentanoate
DC66560 GalNAc-L96-tert-butyl ester GalNAc-L96-tert-butyl ester is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
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