Diclofenac sodium|cas 15307-79-6|DC Chemicals

Cas No.:	15307-79-6
SMILES:	[Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1
Formula:	C₁₄H₁₀Cl₂NNaO₂
M.Wt:	318.13
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.Diclofenac is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. Diclofenac sodium (Dc), an anti-inflammatory agent, has remarkable inhibitory action both against drug-sensitive and drug-resistant clinical isolates of various Gram-positive and Gram-negative bacteria. Dc injected at 1.5 microg/g and 3.0 microg/g mouse body weight significantly protected animals from the lethality of Salmonella infection. In vivo test using 30 or 50 microg Dc per 20 g mouse (Swiss Albino variety) significantly (P <0.001) protected the animals when challenged with 50 MLD of a virulent Salmonella typhimurium. The anti-bacterial action of Dc was found to be due to inhibition of DNA synthesis which was demonstrated using 2 micro Ci (3H) deoxythymidine uptake.

MSDS

COA

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2018-0101

Cat. No.	Product name	Field of application
DC9071	Piroxicam	Piroxicam (Feldene) is a non-selective COX inhibitor with an IC50 of 6 mM.
DC8982	Naproxen	Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
DC9000	Naproxen sodium	Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
DCAPI1565	Loxoprofen Sodium	Loxoprofen is a non-steroidal anti-inflammatory drug that is quickly converted to the trans-alcohol metabolite. It is similar to ibuprofen and naproxen, while also being a Cycloxygenase (COX) inhibitor.
DC9100	Ketorolac Tromethamine	Ketorolac (Ketorolac tromethamine, Toradol) is a non-selective COX inhibitor with strong analgesic activity.
DC9064	Diclofenac sodium	Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.