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Dot1L-IN-4

  Cat. No.:  DC28771  
Chemical Structure
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More than 5000 active chemicals with high quality for research!
Field of application
Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.:
Chemical Name: Dot1L-IN-4
Synonyms: Dot1L-IN-4;BDBM50529550;N4Z
SMILES: ClC1C([H])=C([H])C([H])=NC=1[C@]([H])(C1C([H])=C([H])C([H])=C2C=1OC(O2)(F)F)N([H])C1C([H])=C([H])C(=C([H])C=1N([H])C1N=C(N=C(N=1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])OC([H])([H])[H])S(C([H])([H])[H])(=O)=O
Formula: C28H27ClF2N8O5S
M.Wt: 661.0794
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC47618 PRMT5-IN-10 PRMT5-IN-10 has promising structure-dependent inhibition of the protein methyltransferase PRMT5:MEP50 complex.
DC47617 EED ligand 1 EED ligand 1 is a diverse, potent, and efficacious inhibitor that target the EED subunit of the polycomb repressive complex 2 (PRC2) methyltransferase.
DC47615 PRMT5-IN-9 PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC50 of 0.01 μM.
DC47613 PRMT5-IN-12 PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5.
DC47612 PRMT5-IN-11 PRMT5-IN-11 is a promising structure-dependent inhibition of the protein methyltransferase PRMT5:MEP50 complex in the (sub)micromolar range.
DC47611 PRMT5-IN-14 PRMT5-IN-14 is a PRMT5 inhibitor to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.
DC47610 PRMT5-IN-3 PRMT5-IN-3 is a PRMT5 inhibitor that exhibits synthetic lethality to tumor cells but produce few side effects combined with DNA damaging agents.
DC47609 PRMT1-IN-1 PRMT1-IN-1 is a PRMT1 inhibitor.
DC47608 EZH2-IN-2 EZH2-IN-2 is a EZH2 inhibitor extracted from patent WO2018133795A1, Compound Example 69, with an IC50 of 64 nM. EZH2-IN-2 can be used for the research of cancer or precancerous condition related to EZH2 activity.
DC47264 MS67 MS67 is a potent and selective WD40 repeat domain protein 5 (WDR5) degrader with a Kd of 63 nM. MS67 is inactive against other protein methyltransferases, kinases, GPCRs, ion channels, and transporters. MS67 shows potent acticancer effects.
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