EPZ031686||CAS 1808011-22-4|DC Chemicals

Cas No.:	2095161-11-6
Chemical Name:	EPZ031686
Synonyms:	6-Chloro-2,3-dihydro-2-oxo-N-[(3-endo)-8-[[[1-(4,4,4-trifluorobutyl)-4-piperidinyl]methyl]sulfonyl]-8-azabicyclo[3.2.1]oct-3-yl]-1H-indole-5-carboxamide;EPZ031686
SMILES:	ClC1C(C(=O)N[C@H]2C[C@@H]3N(S(=O)(=O)CC4CCN(CCCC(F)(F)F)CC4)[C@H](C2)CC3)=CC2CC(NC=2C=1)=O
Formula:	C₂₆H₃₄ClF₃N₄O₄S
M.Wt:	591.09
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

EPZ031686 is a noncompetitive inhibitor for SMYD3 and MEKK2 with a Ki=1.2 and 1.1 nM respectively. In vitro: EPZ031686 have a cellular potency at a level sufficient to probe the in vitro biology of SMYD3 inhibition. The first SMYD3 inhibitor identify to show double-digit nanomolar cellular activity. EPZ031686 show < 30% inhibition against 16 histone methyltransferase targets at a 10 uM screening concentration. In vivo: EPZ031686 show good bioavailability following oral dosing in mice. The administration for mice is 1 mg/kg by i.v.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
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