UNC6852
Cat. No.: DC28688
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Field of application
UNC6852 is a selective rolycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a VHL ligand, with an IC50 of 247 nM for EED.
Cas No.: |
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Chemical Name: |
UNC6852 |
Synonyms: |
UNC 6852;UNC-6852;UNC6852 |
SMILES: |
O=C(NCCCC(=O)N[C@@H](C(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1C=CC(C2SC=NC=2C)=CC=1)C1C=CC(C2C3=NN=CN3C(NCC3OC=CC=3)=NC=2)=CC=1 |
Formula: |
C43H48N10O6S |
M.Wt: |
832.969627380371 |
Purity: |
>98% |
Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Publication: |
[1]. Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15. |
MSDS
COA
LOT NO. |
DOWNLOAD |
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2018-0101 |
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2018-0101 |
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