EW-7197

Cas No.:	1352608-82-2
Chemical Name:	Vactosertib
Synonyms:	EW 7197;1H-​Imidazole-​2-​methanamine, N-​(2-​fluorophenyl)​-​5-​(6-​methyl-​2-​pyridinyl)​-​4-​[1,​2,​4]​triazolo[1,​5-​a]​pyridin-​6-​yl-;EW-7197;N-(2-Fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-1H-imidazole-2-methanamine;Vactosertib;TEW-7197;N-(2-Fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazole-2-methanamine;N-[[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1h-imidazol-2-yl]methyl]-2-fluoroaniline;GTPL8107;C22H18FN7;6T4O391P5Y;EX-A1
SMILES:	FC1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=NC(C2C([H])=C([H])C3=NC([H])=NN3C=2[H])=C(C2=C([H])C([H])=C([H])C(C([H])([H])[H])=N2)N1[H]
Formula:	C22H18FN7
M.Wt:	399.4236
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Vactosertib (EW-7197) is an ATP-competitive inhibitor of ALK5 with an IC50 of 12.9 nM. It also inhibits ALK2 and ALK4 at nanomolar concentrations.