Edicotinib（JNJ-40346527）

Cas No.:	1142363-52-7
Chemical Name:	Edicotinib
Synonyms:	4-cyano-N-(2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)pyridin-3-yl)- 1H-imidazole-2-carboxamide;4-Cyano-1H-imidazole-2-carboxylic acid N-[2-(4,4-dimethylcyclohex-1-enyl)-6-(2,2,6,6-tetramethyltetrahydropyran-4-yl)pyridin-3-yl]amide;Edicotinib;JNJ40346527;3NU609VYNF;Edicotinib [USAN];Edicotinib (USAN);US8497376, 15;4-cyano-N-[2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyloxan-4-yl)pyridin-3-yl]-1H-imidazole-2-carboxamide;BNVPFDRNGHMRJS-UHFFFAOYSA-N;GTPL8942;BDBM98634;BDBM276743;BCP25086;US10071991, Compound (P);DB12504;AK549463;D11378;Q27893923;4-Cyano-1H-imidazole-2-carboxylic acid N-(2-(4,4-dimet
SMILES:	O1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])(C2C([H])=C([H])C(=C(C3=C([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C3([H])[H])N=2)N([H])C(C2=NC([H])=C(C#N)N2[H])=O)C([H])([H])C1(C([H])([H])[H])C([H])([H])[H]
Formula:	C27H35N5O2
M.Wt:	461.5991
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Edicotinib（JNJ-40346527）is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS tyrosine kinase inhibitor JNJ-40346527 blocks the receptor-ligand interaction between FMS and its ligand CSF1, thereby preventing autophosphorylation of FMS. As a result, unphosphorylated FMS can not activate FMS-mediated signaling pathways, thus potentially inhibiting cell proliferation in FMS-overexpressed tumor cells. FMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation, recruitment, and activation as well as the regulation of cell proliferation.