Eliprodil

Cas No.:	119431-25-3
Chemical Name:	Eliprodil
Synonyms:	1-(4-Chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethanol;Eliprodil;1-Piperidineethanol, a-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-;Eliprodil,α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol;SL-820715;Α-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL;SL 820715;alpha-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol;1-(4-broMophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethanol;(+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol;SL 820715, α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol;Eliprodil [INN];C20H23ClFNO;1-Piperidineethanol, alpha-(4-chlorophenyl)-4-(4-fluorophenyl)-, (+-)-;DSSTox_RID_81089;DSSTox_CID_25744;DSSTox_GSID_45744;1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanol;(+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperi
SMILES:	ClC1C([H])=C([H])C(=C([H])C=1[H])C([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2C([H])=C([H])C(=C([H])C=2[H])F)C([H])([H])C1([H])[H])O[H]
Formula:	C20H23ClFNO
M.Wt:	347.8541
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Eliprodil(SL-820715) is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptors(IC50> 100 uM).IC50 value:Target: NR2B-NMDA antagonistHuman N-type Ca2+ channel currents were inhibited by ifenprodil and eliprodil with IC50 values of 50 microM and 10 microM respectively whereas P-type Ca2+ channel currents were inhibited reversibly by ifenprodil and eliprodil with approximate IC50 values of 60 microM and 9 microM respectively. eliprodil (1 microm) produced a moderate reverse rate-dependent prolongation of the action potential duration (7.4+/-1.5, 8.9+/-2.1 and 9.9+/-1.8% at cycle lengths of 300, 1000 and 5000 ms, respectively; n=9).

References:

[1]. Bath CP, et al. The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia. Eur J Pharmacol. 1996 Mar 28;299(1-3):103-12. [2]. Lengyel C, et al. Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk. Br J Pharmacol. 2004 Sep;143(1):152-8.