| Cas No.: | 441045-17-6 |
| Chemical Name: | Eribulin Mesilate |
| Synonyms: | Eribulin Mesilate;E7389;11,15:18,21:24,28-Triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2-I]furo[2',3':5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one, 2-[(2S)-3-amino-2-hydroxypropyl]hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)-,2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-,methanesulfonate (salt);Eribulin Mesylate;B1939 mesylate;E7389 mesylate;ER-086526 mesylate;Halaven;Eribulin (mesylate) |
| SMILES: | CS(=O)(O)=O.NC[C@@H](O)C[C@H]1[C@@H](OC)[C@H]2[C@H](C[C@@H]3C(=C)[C@@H](C)C[C@@H](CC[C@H]4C(=C)C[C@@H](O4)CCC56O[C@H]7[C@@H]8[C@@H](O[C@H]7C6)[C@@H](O5)[C@@H]9[C@H](CC[C@H](CC(=O)C2)O9)O8)O3)O1 |
| Formula: | C40H59NO11.CH4O3S |
| M.Wt: | 826.002220000001 |
| Purity: | >99% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Eribulin mesylate is a microtubule targeting agent that is used in the treatment of metastatic breast cancer. It inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. |
| References: | [1]. Okouneva, T., et al., Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase. Mol Cancer Ther, 2008. 7(7): p. 2003-11. [2]. Smith, J.A., et al., Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability. Biochemistry, 2010. 49(6): p. 1331-7. [3]. Towle, M.J., et al., Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res, 2011. 71(2): p. 496-505. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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| 2018-0101 |
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