Exherin (trifluoroacetate)|cas 1135237-88-5|DC Chemicals

Cas No.:	1135237-88-5
Chemical Name:	ADH-1 trifluoroacetate
Synonyms:	Exherin (trifluoroacetate);(4R,7S,10S,13S,16R)-16-acetamido-13-(1H-imidazol-5-ylmethyl)-10-methyl-6,9,12,15-tetraoxo-7-propan-2-yl-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxamide,2,2,2-trifluoroacetic acid;ADH-1 trifluoroacetate;ADH-1 trifluroacetate;Exherin TFA;ADH-1 (trifluoroacetate);4OJ57R316O;ADH-1 Peptide trifluroacetate;NSC729477;L-Cysteinamide, N-acetyl-L-cysteinyl-L-h
SMILES:	O=C([C@@H](NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CC1=CN=CN1)N2)=O)=O)=O)CSSC[C@H](NC(C)=O)C2=O)N.O=C(O)C(F)(F)F
Formula:	C₂₄H₃₅F₃N₈O₈S₂
M.Wt:	684.7087
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Exherin (ADH-1) trifluoroacetate is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities; selectively and competitively binds to and blocks N-cadherin. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis. N-cadherin, a cell- surface transmembrane glycoprotein of the cadherin superfamily of proteins involved in calcium-mediated cell-cell adhesion and signaling mechanisms; may be upregulated in some aggressive tumors and the endothelial cells and pericytes of some tumor blood vessels.

MSDS

COA

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2018-0101

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ADH-1 trifluoroacetate