FCCP|cas 370-86-5|DC Chemicals

Cas No.:	370-86-5
Chemical Name:	Carbonyl cyanide p-trifluoromethoxyphenylhydrazone
Synonyms:	Propanedinitrile,2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-;Carbonyl Cyanide 4-(Trifluoromethoxy)phenylhydrazone;FCCP;{[4-(Trifluoromethoxy)phenyl]-hydrazono}malononitrile;2-[[4-(trifluoromethoxy)phenyl]hydrazinylidene]propanedinitrile;2-{2-[4-(trifluoromethoxy)phenyl]hydrazono}malononitrile;CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYL HYDRAZONE;FCCP,Mesoxalonitrile 4-trifluoromethoxyphenylhydrazone;[4-(Trifluoromethoxy)phenyl]carbonohydrazonoyl Dicyanide;[4-(Trifluoromethoxy)phenylhydrazono]malononitrile;Carbonyl cyanide [4-(trifluoromethoxy)phenyl]hydrazone;Carbonyl cyanide [p-(trifluoromethoxy)phenyl]hydrazone;FCCCP;Trifluoromethoxy carbonylcyanide phenylhydrazone;Carbonyl cyanide p-trifluoromethoxyphenylhydrazone;Propanedinitrile, [[4-(trifluoromethoxy)phenyl]hydrazono]-;Propanedinitrile, ((4-(trifluoromethoxy)phenyl)hydrazono)-;Carbonyl cyanide 4-trifluoromethoxyphenylhydrazone;Carbonyl cyanide, 4-trifluoromethoxyphenylhydrazone;((4-(Trifluoro
SMILES:	FC(OC1C([H])=C([H])C(=C([H])C=1[H])N([H])/N=C(\C#N)/C#N)(F)F
Formula:	C₁₀H₅F₃N₄O
M.Wt:	254.1681
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

FCCP is an uncoupler of oxidative phosphorylation in mitochondria.

In Vitro:

FCCP (5 μM) results in a concentration-dependent decrease in Aβ and APPsβ production in K695sw cells. FCCP inhibits processing of wild-type APP. FCCP does not alter cellular ATP levels at any of the concentrations measured. The effects of FCCP on APP catabolism are independent of secondary effects on oxidative phosphorylation or the result of reduced cell viability. FCCP (5 μM or 500 nM), baf A1, and NH4Cl induce changes in Tf-Tx and Tf-F cellular fluorescence in K695 cells[1]. FCCP (200 nM) protects and enhances the follicle integrity in cat ovarian tissue during short-term in vitro culture. But FCCP does not appear to exert a beneficial or detrimental effect during ovarian tissue cryopreservation[2].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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