Felbamate

  Cat. No.:  DC5099   Featured
Chemical Structure
25451-15-4
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More than 5000 active chemicals with high quality for research!
Field of application
Felbamate (Felbatol) is an anticonvulsant drug used in the treatment of epilepsy.
Cas No.: 25451-15-4
Chemical Name: 1,3-Propanediol, 2-phenyl-, dicarbamate (8CI,9CI); Carbamic acid, 2-phenyltrimethylene ester
Synonyms: Felbatol
SMILES: NC(OCC(C1=CC=CC=C1)COC(N)=O)=O
Formula: C11H14N2O4
M.Wt: 238.24
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Felbamate (FBM) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .Felbamate (marketed under the brand name Felbatol by MedPointe) is an anti-epileptic drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drugs usage to severe refractory epilepsy.Felbamate has been proposed to a unique dual mechanism of action as a positive modulator of GABAA receptors and as a blocker of NMDA receptors, particularly isoforms containing the NR2B subunit. Although it is clear that felbamate does cause pharmacological inhibition of NMDA receptor of relevance of NMDA receptor blockade as a strategy for the treatment of human epilepsy has been questioned. Therefore, the importance of the effects of felbamate on NMDA receptors to its therapeutic action in epilepsy is uncertain.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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