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Pramipexole 2HCL monohydrate

  Cat. No.:  DC9043   Featured
Chemical Structure
191217-81-9
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Field of application
Pramipexole dihydrochloride hydrate is a selective dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride hydrate can be used for the resear
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 191217-81-9
Chemical Name: Pramipexole dihydrochloride monohydrate
Synonyms: Pramipexole dihydrochloride monohydrate;(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride monohydrate;(6S)-N'-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrate dihydrochloride;Pramipexole 2HCl Monohydrate;Pramipexole;Pramipexole 2HCl Hydrate;Pramipexole dihydrochloride;Pramipexole-;(S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride PPX dihydrochloride;Pramipexole dihydroch;(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole Dihydrochloride Monohydrate;Mirapex;Pra-API;Unii-3D867np06j;PPX dihydrochloride;Pramipexole HCl hydrate;Mirapex,Sifrol,Mirapexin;PraMipexole dihydrochloride Monohy;PraMipexole dihydrochloride hydrate
SMILES: O.Cl.Cl.CCCNC1CCC2N=C(SC=2C1)N
Formula: C10H21Cl2N3Os
M.Wt: 302.2642390728
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Pramipexole dihydrochloride hydrate is a selective dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride hydrate can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS). Pramipexole dihydrochloride hydrate can cross the blood-brain barrier (BBB)[1][2][3].
In Vivo: Pramipexole dihydrochloride hydrate (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals[5]. Pramipexole dihydrochloride hydrate improves neurological recovery[5]. Pramipexole dihydrochloride hydrate prevents ischemic cell death via mitochondrial pathways in ischemic stroke[5]. Animal Model: Male Wistar rats weighing 250-300 g (16-18 weeks old)[5] Dosage: 0.25 mg/kg, 1 mg/kg Administration: Intraperitoneal injection, at 1 hour, 6 hours, 12 hours, 18 hours post-occlusion Result: Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.
In Vitro: Pramipexole dihydrochloride hydrate (0.01-10 μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size[3]. Pramipexole dihydrochloride hydrate attenuates levodopa-induced toxicity in mesencephalic cultures, suggests that pramipexole may be cytoprotective to dopamine neurons in tissue culture[4].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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