Flavopiridol Hydrochloride|cas 131740-09-5|DC Chemicals

Cas No.:	131740-09-5
Chemical Name:	Flavopiridol hydrochloride
Synonyms:	Flavopiridol hydrochloride;(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride;Flavopiridol HCl;2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one,hydrochloride;Flavopiridol (Alvocidib) HCl;Flavopiridol (Hydrochloride);Flavopiridol hydrochloride(Alvocidib hydrochloride);Alvocidib hydrochloride;HL 275;HL-275;HMR-1275;MDL 107826A;NSC 649890;L-86-8276;Alvocidib HCL;NSC 649890 HCl;Flavopiridol HCI;HMR 1275;D48MS3A6N9;Alvocidib hydrochloride [USAN];DSSTox_RID_83155;DSSTox_CID_28887;DSSTox_GSID_48961;L 86 8275;Alvocidib hydrochloride (USAN);2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride;(-)-2-(2-chl
SMILES:	ClC1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C(C2C(=C([H])C(=C(C=2O1)[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])O[H])O[H])O[H])=O.Cl[H]
Formula:	C₂₁H₂₁Cl₂NO₅
M.Wt:	438.3011
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Flavopiridol Hydrochloride is a broad inhibitor of CDK, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively.

In Vitro:

Flavopiridol (2 μM) robustly induces a distinct pattern of ER stress in CLL cells that contributes to cell death through IRE1-mediated activation of ASK1 and possibly downstream caspases[1]. Flavopiridol results in potent upregulation of a number of PRGs in treatments lasting 4-24 h. Flavopiridol has and immediate and long-term effect on the expression of several PRGs. In serum starved cells re-stimulated with serum, flavopiridol also inhibits the expression of these genes, but subsequently, JUNB, GADD45B and EGR1 are upregulated in the presence of flavopiridol[2].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
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DC7297	SNS-032(BMS-387032)	SNS-032(BMS-387032) is a potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively).
DC8780	Flavopiridol Hydrochloride	Flavopiridol hydrochloride competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA.
DC7114	Dinaciclib (SCH727965)	Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively.
DC1025	AT7519 HCL	AT7519 is a novel multi-CDK inhibitor for CDK1/cyclin B, CDK2/Cyclin A, CDK3/Cyclin E, CDK4/Cyclin D1, CDK5/p35 and CDK6/Cyclin D3 with IC50 of 210 nM, 47 nM, 360 nM, 100 nM, 13 nM and 170 nM, respectively.
DC9676	AT7519	AT7519 is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM; less potent to CDK3 and little active to CDK7.