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Fludarabine phosphate

  Cat. No.:  DC4190   Featured
Chemical Structure
75607-67-9
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Field of application
Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 75607-67-9
Chemical Name: Fludarabine phosphate
Synonyms: Fludarabine Phosphate;9-beta-d-arabinofuranosyl-2-fluoroadenine5’-monophosphate;fludarabinemonophosphate;9-bata-d-arabinofuranosyl-2-fluoroadenine phosphate;9-BETA-D-ARABINOFURANOSYL-2-FLUOROADENINE-5'-DIHYDROGEN PHOSPHATE;FLUDARUBINE PHOSPHATE;FludarabinePhosphateFdaInspected;FludarabinePhosphateUsp28;FLUDARABIN PHOSPHATE,USP30;Fludarabine (phosphate);Fludarabine 5'-Phosphate;2-Fluoro-9-(5-O-phosphono-β-D-arabinofuranosyl)-9H-purin-6-amine;2-fluoro-araamp;2-fluoro-ara-C-5'-O-phosphate;FAMP;F-ara-AMP;Fludarabin Phosphate;fludarabine;fludarabine hcl;Fludarabine Phosphate (Fludara);Fludura;9-(β-D-Arabinofuranosyl)-2-fluoroadenine 5'-Monophosphate;2-F-ara-AMP;2-Fluoroadenine 9-β-D-Arabinofuranoside 5'-Monophosphate;fludara;Fludarabine 5'-monophosphate;Oforta;2-Fluoro-ARA AMP;Fludarabine monophosphate;C10H13FN5O7P;2-Fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine;2-Fluoroadenine arabinoside 5'-monophosphate;1X9VK9O1SC;9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate;9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate;CHE
SMILES: O=P(O)(OC[C@H]1O[C@@H](N2C=NC3=C(N)N=C(F)N=C23)[C@@H](O)[C@@H]1O)O
Formula: C10H13FN5O7P
M.Wt: 365.2117
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Fludarabine (phosphate) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
In Vivo: F-araAMP (100 mg/kg given 15 times, 167 mg/kg given 9 times, or 250 mg/kg given 3 times, i.p.) leads to complete regressions of all tumors and cures of all mice. Parental D54 tumors (i.e. without E. coli PNP) are not sensitive to treatment with F-araAMP. Intratumoral injection of Ad/PNP followed by IT F-araAMP can elicit a substantial regressive effect on otherwise refractory solid tumors in a fashion substantially superior to viral PNP transduction followed by systemic prodrug administration[1]. The comparison of ACE-GFP/fludarabine phosphate with ACE-GFP/PBS demonstrats that fludarabine phosphate alone has no growth inhibitory activity on KU-19-19 tumors[2].
In Vitro: Fludarabine phosphate significantly reduces the cell viability in a dose-dependent manner. Fludarabine phosphate exhibits no effect in all tested concentrations when combined with either PBS or control vector, ACE-GFP. Fludarabine phosphate causes a significant decrease in cell viability for 24 h after exposure to ACE-PNP when compared to PBS and ACE-GFP at concentrations of 2.5, 5 and 10 μg/mL[2].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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