GMX1778(CHS-828)

  Cat. No.:  DC8139   Featured
Chemical Structure
200484-11-3
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More than 5000 active chemicals with high quality for research!
Field of application
CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity.
Cas No.: 200484-11-3
Chemical Name: 2-[6-(4-Chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine
Synonyms: CHS 828;CHS-828;GMX1778;GMX-1778;N-Cyano-N'-(4-nitrophenyl)thiourea;N-cyano-N'-(6-(p-chlorophenoxy)hexyl)-N"-(4-pyridyl)guanidine;Thiourea,N-cyano-N'-(4-nitrophenyl);N-[6-(4-Chlorophenoxy)hexyl]-N′-cyano-N′′-4-pyridinyl-guanidine;GMX 1778;CHS828;GMX1778 (CHS828);8LAP87DNSZ;2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine;Guanidine, N-[6-(4-chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinyl-;N-Cyano-N'-(6-(p-chlorophenoxy)hexyl)-N'-(4-pyridyl)guanidine;Guanidine, N-(6-(4-chlorophenoxy)hexyl)-N'-cyano-N''-4-pyridinyl-;BDBM81396
SMILES: ClC1C([H])=C([H])C(=C([H])C=1[H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/N=C(\N([H])C#N)/N([H])C1C([H])=C([H])N=C([H])C=1[H]
Formula: C19H22ClN5O
M.Wt: 371.8639
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: GMX1778(CHS-828) is a potent inhibitor of NAD+ biosynthesis enzyme NAMPT with IC50 <25 nM.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC7573 STF-118804 STF-118804 is a highly specific NAMPT inhibitor.
DC8139 GMX1778(CHS-828) CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity.
DC6901 Daporinad(FK866,APO866) APO866 effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 of 0.09 nM.
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