GSK4112|cas: 1216744-19-2|DC Chemicals

Cas No.:	1216744-19-2
Chemical Name:	SR6452; SR-6452; SR 6452;GSK4112;GSK-4112;GSK 4112
Synonyms:	SR6452; SR-6452; SR 6452;GSK4112;GSK-4112;GSK 4112
SMILES:	ClC1C=CC(CN(CC2=CC=C([N+]([O-])=O)S2)CC(OC(C)(C)C)=O)=CC=1
Formula:	C₁₈H₂₁ClN₂O₄S
M.Wt:	396.89
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

GSKGSK4112 is a Rev-erbα agonist with EC50 of 0.4 μM, also is a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα

In Vitro:

GSK4112 profiled as a Rev-erb agonist in cells to inhibit expression of the circadian target gene bmal1. In addition, GSK4112 repressed the expression of gluconeogenic genes in liver cells and reduced glucose output in primary hepatocytes. Therefore, GSK4112 is useful as a chemical tool to probe the function of Rev-erb in transcriptional repression, regulation of circadian biology, and metabolic pathways. Additionally, GSK4112 may serve as a starting point for design of Rev-erb chemical probes with in vivo pharmacologicalm activity.

MSDS

COA

LOT NO.	DOWNLOAD
2018-0101
2018-0101

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