Cas No.: | 1337531-36-8 |
Chemical Name: | 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyrimidin-4-amine |
Synonyms: | GSK2606414,GSK-2606414,GSK 2606414 |
SMILES: | C1=CC(C2C3C(N)=NC=NC=3N(C)C=2)=CC2CCN(C(=O)CC3=CC=CC(C(F)(F)F)=C3)C1=2 |
Formula: | C24H20F3N5O |
M.Wt: | 451.44 |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | GSK2606414 is a cell-permeable and orally available PERK inhibitor with an IC50 of 0.4 nM. |
In Vivo: | GSK2606414 (50 and 150 mg/kg, p.o.) inhibits the growth of a human tumor xenograft in mice[1]. |
In Vitro: | GSK2606414 inhibits PERK activation in cells[1]. |