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| Cas No.: | 83797-69-7 |
| Chemical Name: | 6-n-Octylaminouracil |
| Synonyms: | 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione;GTPL5846;6-OAU;6-n-octylaminouracil;6-(octylamino)-1H-pyrimidine-2,4-dione;2,4(1H,3H)-Pyrimidinedione, 6-(octylamino)-;6-(Octylamino)-2,4(1H,3H)-pyrimidinedione;6-n-octyl aminouracil;AOB5243;BCP14892;BDBM50189502;Q27074016;6-(octylamino)-1,2,3,4-tetrahydropyrimidine-2,4-dione |
| SMILES: | O=C1N([H])C(C([H])=C(N1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=O |
| Formula: | C12H21N3O2 |
| M.Wt: | 239.3140 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | 6-OAU(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay. |
| In Vivo: | Injection of 6-OAU suspension in 1% rat serum into the rat jugular vein (10 mg/kg) leads to the elevation of a chemokine, CXCL1 concentration in the serum peaking at 3 h after the injection. In the rat air pouch model, 6-OAU at 1 mg/ml dissolved in 0.3% BSA attracted both PMNs and macrophages into the air pouch, peaking at 4 h after 6-OAU inoculation [1]. |
| In Vitro: | 6-OAU increased [35S]GTPγS incorporated in Sf9 cell membranes expressing human GPR84-Gαi fusion protein with an EC50 of 512 nM. 6-OAU did not activate human GPR40 in HEK293 cells in the PI assay. Stimulation with 6.25 μm 6-OAU began to induce GPR84-EGFP internalization, and the extensive internalization was observed at 200 μm 6-OAU stimulation. In a Transwell assay, 3-OH-C12 and the surrogate agonist, 6-OAU, provoked chemotaxis of PMNs prepared from human peripheral blood in a concentration-dependent manner with an EC50 of 24.2 μm and 318 nm, respectively. In addition, 3-OH-C12 and 6-OAU increased the secretion of IL-8 from LPS-stimulated PMNs [1] |
| References: | [1]. Suzuki M, et al. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. J Biol Chem. 2013 Apr 12;288(15):10684-91. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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