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Giredestrant

  Cat. No.:  DC40118   Featured
Chemical Structure
1953133-47-5
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More than 5000 active chemicals with high quality for research!
Field of application
Giredestrant (GDC-9545), a non-steroidal estrogen receptor (ER) ligand, is an orally active and selective ER antagonist. Giredestrant potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Gir
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1953133-47-5
Chemical Name: Giredestrant
Synonyms: Giredestrant;28P3DU6DB3;Giredestrant [INN];GQCXHIKRWBIQMD-AKJBCIBTSA-N;3-((1R,3R)-1-(2,6-Difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-pyrido(3,4-b)indol-2-yl)-2,2-difluoropropan-1-ol;3-[(1R,3R)-1-[2,6-difluoro-4-[[1-(3-fluoropropyl)azetidin-3-yl]amino]phenyl]-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-2,2-difluoro-propan-1-ol;2H-Pyrido(3,4-b)indole-2-propanol, 1-(2,6-difluoro-4;GDC-9545
SMILES: FC(CO)(CN1[C@H](C)CC2C3=CC=CC=C3NC=2[C@H]1C1C(=CC(=CC=1F)NC1CN(CCCF)C1)F)F
Formula: C27H31F5N4O
M.Wt: 522.553263902664
Sotrage: Powder-20°C3 years 4°C2 yearsIn solvent-80°C6 months-20°C1 month
Description: Giredestrant (GDC-9545), a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist. Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity[1].
In Vitro: Giredestrant (GDC-9545) is a novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes. The highly potent in vivo efficacy of Giredestrant likely arises due to the particular combination of high binding potency, full suppression of ER signaling, and an improved DMPK profile[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
Cat. No. Product name Field of application
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