H-Val-Pro-Pro-OH TFA

Cas No.:	2828433-08-3
Chemical Name:	(S)-1-((S)-1-((S)-2-Amino-3-methylbutanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid trifluoroacetate
Synonyms:	(S)-1-((S)-1-((S)-2-Amino-3-methylbutanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid trifluoroacetate;H-Val-Pro-Pro-OH TFA;CS-0077836;G16510;VPP TFA;2828433-08-3;HY-114161A;H-Val-Pro-Pro-OH (TFA);(2S)-1-[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid;2,2,2-trifluoroacetic acid;MS-27486
SMILES:	C(F)(F)(F)C(=O)O.C(N1CCC[C@H]1C(=O)O)([C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)=O
Formula:	C₁₇H₂₆F₃N₃O₆
M.Wt:	425.400055408478
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

In Vitro H-Val-Pro-Pro-OH (TFA), a proline peptides derivative, could inhibit Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM. H-Val-Pro-Pro-OH (TFA) could enhance insulin sensitivity and prevent insulin resistance in 3T3-F442A pre-adipocytes. H-Val-Pro-Pro-OH (TFA) also has anti-hypertensive and anti-inflammatory functions. H-Val-Pro-Pro-OH (TFA) further enhances the expression of glucose transporter 4 (GLUT4) in adipocytes and restores glucose uptake in TNF-treated adipocytes.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC40211	H-Ile-Pro-Pro-OH hydrochloride	H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5 μM. Antihypertensive tripeptides.
DC12255	MLN-4760	MLN-4760 is a potent and selective human ACE2 inhibitor (IC50, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).
DC12262	H-Val-Pro-Pro-OH TFA	H-Val-Pro-Pro-OH (TFA) is a trifluoroacetate (TFA) salt form of the tripeptide H-Val-Pro-Pro-OH, which is derived from milk proteins. This peptide is known for its ability to inhibit Angiotensin I Converting Enzyme (ACE), a key enzyme in the renin-angiotensin system (RAS) that regulates blood pressure. The TFA salt form is commonly used in research and pharmaceutical applications to improve the solubility and stability of the peptide.
DC9325	Cilazapril (monohydrate)	Cilazapril Monohydrate is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure.