| Description: |
Stemolecule Wnt Inhibitor IWP-3 was identified in a high throughput screen For antagonists of the Wnt/β-catenin pathway. Wnt Inhibitor IWP-3 prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity. It also blocks phosphorylation of the Lrp6 receptor and accumulation of both Dvl2 and β-catenin. The inhibition of the Wnt pathway through the use of IWP-3 has also been shown to promote the Formation of cardiocytes from human embryonic stem cell-derived mesoderm cells.For the detailed information of IWP-3, the solubility of IWP-3 in water, the solubility of IWP-3 in DMSO, the solubility of IWP-3 in PBS buffer, the animal experiment (test) of IWP-3, the cell expriment (test) of IWP-3, the in vivo, in vitro and clinical trial test of IWP-3, the EC50, IC50,and Affinity of IWP-3, Please contact DC Chemicals. |
