JH-II-127

Cas No.:	1700693-08-8
Chemical Name:	[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-ylmethanone
Synonyms:	JH-II-127;(4-((5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)(morpholino)methanone;[4-[[5-Chloranyl-4-(Methylamino)-7~{h}-Pyrrolo[2,3-D]pyrimidin-2-Yl]amino]-3-Methoxy-Phenyl]-Morpholin-4-Yl-Methanone;BCP16207;SB19025;AK473658;A15777;A1K;[4-[[5-chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amin;[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-morpholin-4-yl
SMILES:	ClC1=C([H])N([H])C2=C1C(N([H])C([H])([H])[H])=NC(=N2)N([H])C1C([H])=C([H])C(=C([H])C=1OC([H])([H])[H])C(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])=O
Formula:	C19H21ClN6O3
M.Wt:	416.8614
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T.IC50 value: 2.2 n(LRRK2-G2019S), 6.6 nM(LRRK2-wild-type), 47.7 nM (LRRK2-A2016T)Target: LRRK2JH-II-127 is a potent and selective inhibitor of both wild-type and G2019S mutant LRRK2. JH-II-127 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0.1-0.3 μM in a variety of cell types and is capable of inhibiting Ser935 phosphorylation in mouse brain following oral delivery of doses as low as 30 mg/kg.