JK-P3|cas 942655-44-9|DC Chemicals

Cas No.:	942655-44-9
Chemical Name:	3,4-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)benzamide
Synonyms:	3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide;JK-P3;3,4-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)benzamide;BCP32785;N16805;Q27455260;4Y0;3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)benzamide (ACI);3,4-Dimethoxy-N-(3-phenyl-1H-pyrazol-5-yl)benzamide
SMILES:	O(C)C1=C(C=CC(=C1)C(NC1C=C(C2C=CC=CC=2)NN=1)=O)OC
Formula:	C₁₈H₁₇N₃O₃
M.Wt:	323.352
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

JK-P3 is a VEGFR-2 inhibitor. JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50 = 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube formation in HUVEC without effecting endothelial cell proliferation.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
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DC1082	ZM306416	ZM306416 is a vascular endothelial growth factor receptor (VEGFR) antagonist.
DC1097	XL-184 (Cabozantinib,BMS907351)	XL184 (Cabozantinib) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.
DC11268	VEGFR2 kinase inhibitor I(SU-5408)	VEGFR2 kinase inhibitor I(SU-5408)is a potent, cell-permeable inhibitor of mouse VEGFR2 kinase (IC50 = 70 nM).
DC3134	Vandetanib (ZD6474)	Vandetanib (Zactima, ZD6474) is a potent inhibitor of VEGFR2 with IC50 of 40 nM.
DC9586	Telatinib	Telatinib(Bay 57-9352) is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRα with IC50 of 6 nM/4 nM, 1 nM and 15 nM, respectively.
DC12256	TAS-115 mesylate (TAS-115 methanesulfonate)	TAS-115 mesylate is a potent VEGFR and c-Met/HGFR kinase inhibitor with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively.
DC3146	Sunitinib malate	Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.
DC9781	SU4312(NSC86429)	SU4312(NSC86429) is a selective, cell-permeable inhibitor of VEGFR2 and PDGFR tyrosine kinases (IC50s = 0.8 and 19.4 μM, respectively).
DC7509	SU1498	SU1498 is a selective inhibitor of the VEGFR2; inhibits Flk-1with an IC50 of value of 700 nM.