| Cas No.: | 1627902-21-9 |
| SMILES: | ClC1=C(C=CC=C1C(N2CCC3=C(N=NN3C4=NC=C(F)C=N4)[C@H]2C)=O)C(F)(F)F |
| Formula: | C18H13ClF4N6O |
| M.Wt: | 440.78 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | In Vitro JNJ-54175446 (Compound 14) is a potent and selective brain penetrant P2X7 antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 and rP2X7, respectively. JNJ-54175446 shows less potent activity against mouse, dog and Macaque P2X7 (pIC50, 7.8, 7.9 and 8.1, respectively). In Vivo JNJ-54175446 shows dose-dependent occupancy with the ED50 of 0.46 mg/kg, corresponding to plasma EC50 of 105 ng/mL. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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