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K02288

  Cat. No.:  DC7742   Featured
Chemical Structure
1431985-92-0
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More than 5000 active chemicals with high quality for research!
Field of application
K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1431985-92-0
Chemical Name: 3-[6-Amino-5-(3,4,5-Trimethoxyphenyl)pyridin-3-Yl]phenol
Synonyms: K 02288;3-[6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;K02288​;K-02288;3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;3-[6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-phenol;3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol;K02288;3-(6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenol;A3F;SYN5187;AOB4291;HMS3653M16;BDBM102619;K02288a;BCP09946;s7359;K 02288a;FD5034;SB19486;BC600483;AK175599;Y1876;K02288, >98% (HPLC);SW220200-1;A14311;Phenol
SMILES: O(C([H])([H])[H])C1C(=C(C([H])=C(C=1[H])C1=C(N([H])[H])N=C([H])C(C2C([H])=C([H])C([H])=C(C=2[H])O[H])=C1[H])OC([H])([H])[H])OC([H])([H])[H]
Formula: C20H20N2O4
M.Wt: 352.3838
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: K02288 is a potent inhibitor of ALK, and inhibits ALK1/2/3/6 with IC50s of 1.8/1.1/34.4/6.3 nM; K02288 is less potent against ALK4/5, with IC50s of 302 nM and 321 nM.
In Vivo: K02288 (1 µM) induces dysfunctional angiogenesis in a chick embryo CAM model[2].
In Vitro: K02288 reduces a robust phosphorylation of Smad1/5/8 induced by BMP4 stimulation, with an apparent IC50 of 100 nM. K02288 causes near complete inhibition of Smad2 phosphorylation at 0.5 µM[1]. K02288 binds to ALK1 in an ATP-mimetic fashion with two hydrogen bonds to the kinase hinge. K02288 also inhibits BMP9-ALK1 signalling, and induces a hypersprouting phenotype in HUVECs[2].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC7739 SD-208 SD-208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50= 49 nM)
DC6312 SB525334 SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.
DC5189 SB-431542 SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold more selective for ALK5 than p38 MAPK and other kinases.
DC7259 Repsox（ALK5 Inhibitor II） RepSox(E-616452; SJN 2511) is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively.
DC7587 ML347 ML347 is a selective BMP receptor inhibitor with IC50 of 32 nM for ALK2, >300-fold selectivity over ALK3. Also inhibits ALK1 activity with IC50 of 46 nM
DC10675 LY3200882 LY3200882 is a novel, highly selective TGFβRI small molecule inhibitor.
DC6306 LY2157299(Galunisertib) LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. Phase 2.
DC7914 LDN-214117 LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM; > 100 fold selectivity for ALK5; also inhibits BMP6(IC50=100 nM).
DC7742 K02288 K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.
DC8028 ITD-1 ITD-1 is a novel and highly selective TGFβ pathway inhibitor. ITD-1 molecule turns stem cells into heart cells.
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