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L67

  Cat. No.:  DC8790   Featured
Chemical Structure
325970-71-6
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More than 5000 active chemicals with high quality for research!
Field of application
L67 is a novel, competitive human DNA ligase inhibitor, inhibits DNA ligases I and III with IC50 of 10 μM and 10 μM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 325970-71-6
Chemical Name: L67
Synonyms: L67;DNA Ligase Inhibitor;L-67;N-(3,5-Dibromo-4-methylphenyl)-glycine 2-[(2-hydroxy-5-nitrophenyl)methylene]hydrazide;III inhibitor L67;LigI;LigI/III inhibitor L67
SMILES: BrC1=CC(NCC(N/N=C/C2=CC([N+]([O-])=O)=CC=C2O)=O)=CC(Br)=C1C
Formula: C16H14N4O4Br2
M.Wt: 486.115
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: L67 is a novel, competitive human DNA ligase inhibitor, inhibits DNA ligases I and III with IC50 of 10 μM and 10 μM.IC50 value: 10 μM [1]Target: DNA ligasesin vitro: L67 significantly increases the cytotoxicity of DNA damaging agents.[1] L67 also inhibits cell proliferation. [2]
References: [1]. Zhong S, et al. Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem. 2008 Aug 14;51(15):4553-4562. [2]. Chen X, et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 2008 May 1;68(9):3169-3177.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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