L-006,235|cas 294623-49-7|DC Chemicals

Cas No.:	294623-49-7
Chemical Name:	N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide
Synonyms:	Benzamide, N-[1-[[(cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-pipera zinyl)-4-thiazolyl]-;I-006,235;L 006235;N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamide;L006235;N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(4-methylpiperazin-1-yl)thiazol-4-yl)benzamide;BDBM19854;BCP28510;basic piperazine-containing compound, 1;Benzamide, N-[1-[[(cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]-;L-006235
SMILES:	C1=C(C(NC2(CCCCC2)C(=O)NCC#N)=O)C=CC(C2N=C(N3CCN(C)CC3)SC=2)=C1
Formula:	C₂₄H₃₀N₆O₂S
M.Wt:	466.599003314972
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

L-006,235 is a potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. Displays reduced selectivity in cell-based assays possibly due to lysosomal accumulation. Reduces collagen breakdown and promotes bone deposition in vivo. Orally active and has intrinsic fluorescence. For the detailed information of L-006,235, the solubility of L-006,235 in water, the solubility of L-006,235 in DMSO, the solubility of L-006,235 in PBS buffer, the animal experiment (test) of L-006,235, the cell expriment (test) of L-006,235, the in vivo, in vitro and clinical trial test of L-006,235, the EC50, IC50,and affinity,of L-006,235, Please contact DC Chemicals.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC6401	Odanacatib (MK 0822)	Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of human and rabbit cathepsin K with IC50 of 0.2 nM and 1 nM , respectively.
DC7934	L-006,235	L 006235 is a reversible and potent cathepsin K inhibitor that displays more than a 4000 fold selectivity over cathepsins B, L and S.
DC8485	E-64d(Aloxistatin)	E-64D is an inhibitor of cathepsins B and L; also thought to inhibit calpain,showed a potent activity for COVID-19(SARS-COV-2)with EC50: MERS-COV(1.275),SARS-COV(0.760)
DC7697	CA-074-Me	CA-074 Me is a selective and cell-permeable inhibitor of cathepsin B.
DC7371	Balicatib	Balicatib(AAE-581) is a potent and selective inhibitor of cathepsin K; 10-100-fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S.