Lorediplon

Cas No.:	917393-39-6
Chemical Name:	Lorediplon
Synonyms:	Lorediplon;N-[2-fluoro-5-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-N-methylacetamide;VKU6Z23NSY;Lorediplon [INN];NQPOCLFSADOXBR-UHFFFAOYSA-N;BCP24663;SB16784;N-(2-Fluoro-5-(3-(thiophene-2-carbonyl)pyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-methylacetamide;AK548104;Acetamide, N-(2-fluoro-5-(3-(2-thienylcarbonyl)pyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-methyl-;Q6680290;N-{2-fluoro-5-[3-(thiophene-2-carbonyl)-pyrazolo[1,5-a]pyrimidin-7-yl]-phenyl}-N-met
SMILES:	S1C([H])=C([H])C([H])=C1C(C1C([H])=NN2C=1N=C([H])C([H])=C2C1C([H])=C([H])C(=C(C=1[H])N(C(C([H])([H])[H])=O)C([H])([H])[H])F)=O
Formula:	C20H15FN4O2S
M.Wt:	394.4221
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Lorediplon is a novel non-benzodiazepine, hypnotic drug acting as a GABAA receptor modulator, differentially active at the alpha1-subunit, associated with promoting sleep.Target: GABALorediplon is a drug for the treatment of insomnia, has been successfully completed with a best-in-class efficacy profile in terms of maintaining sleep and sleep quality, Lorediplon targets GABAA. [1] Lorediplon demonstrates a minimum of 10-fold and 6-fold increase in potency (respectively) in the spontaneous motor activation studies. At concentrations of 1.2mg/kg, Lorediplon demonstrates a 57%increased effect on Slow Wave Sleep (SWS), when compared with a placebo.[2]