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Home > Inhibitors & Agonists > Proteasome/Ubiquitin > Proteasome

MG-101

  Cat. No.:  DC7702   Featured
Chemical Structure
110044-82-1
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More than 5000 active chemicals with high quality for research!
Field of application
MG-101 is a calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 110044-82-1
Chemical Name: L-Leucinamide,N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-
Synonyms: L-Leucinamide,N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-;CALPAIN INHIBITOR I;MG 101;MG-101 (ALLN);NULL;Ac-Leu-Leu-Nle-al;AC-LEU-LEU-NLE-CHO;AC-LEU-LEU-NORLEUCINAL;ac-llnl-cho;AC-LL-NORLEUCINAL;ALL;ALLN;ALLN Ac-LLnL-CHO MG-101 N-Acetyl-Leu-Leu-Norleu-al N-Acetyl-L-leucyl-L-leucyl-L-norleucinal;CALPAIN INHIBITOR;Calpain Inhibitor I,ALLN;LLNL;MG-101;N-Acetyl-Leu-Leu-Norleu-al;N-Acetyl-L-leucyl-L-leucyl-L-norleucinal;n-acetyl-leu-leu-norleucinal;N-Acetyl-L-leucinyl-L-leucinyl-L-norleucinal;InSolution? ALLN
SMILES: O=C(N[C@H](C=O)CCCC)[C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C
Formula: C20N3O4H37
M.Wt: 383.5255
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: MG-101 is a potent inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively.
References: [1]. Li SZ, et al. ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. Biochem Biophys Res Commun. 2013 Jul 26;437(2):325-330.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC71617 Suc-Gly-Gly-Phe-pNA(chymotrypsin substrate) The synthetic peptide Suc-Gly-Gly-Phe-pNA serves as a specific substrate for the enzyme chymotrypsin, demonstrating a Michaelis constant (Km) of 1.6 mM. This value reflects the substrate concentration at which the enzyme achieves half of its maximum reaction rate, indicating its affinity for the peptide.
DC70579 M3258 M3258 (M 3258) is a potent, reversible, highly selective and orally acitve LMP7 inhibitor with ceullar IC50 of 4.1 nM.M3258 does not inhibit other constitutive proteasome and immunoproteasome subunits (IC50>2.5 uM).M3258 demonstrated strong antitumor efficacy in multiple myeloma xenograft models.M3258 treatment led to a significant and prolonged suppression of tumor LMP7 activity and ubiquitinated protein turnover and the induction of apoptosis in multiple myeloma cells both in vitro and in vivo.M3258 showed superior antitumor efficacy in selected multiple myeloma and mantle cell lymphoma xenograft models compared with the approved nonselective proteasome inhibitors bortezomib and ixazomib.
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DC8747 PD 151746 PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain.
DC8283 PD 150606 PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively).
DC2010 Oprozomib (ONX-0912) Oprozomib (ONX 0912) selectively inhibits CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM.
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