MK-8998

Cas No.:	953778-58-0
Chemical Name:	(R)-2-(4-Isopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide
Synonyms:	(R)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide;MK 8998;MIA4WMP8QN;2-(4-propan-2-ylphenyl)-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]acetamide;BCP18693;BDBM50192668;MK8998;2-(4-isopropylphenyl)-n-[(1r)-1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl]acetamide;Benzeneacetamide, 4-(1-methylethyl)-N-((1R)-1-(5-(2,2,2-trifluoroethoxy)-2-pyri
SMILES:	FC(C([H])([H])OC1=C([H])N=C(C([H])=C1[H])[C@@]([H])(C([H])([H])[H])N([H])C(C([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])C([H])(C([H])([H])[H])C([H])([H])[H])=O)(F)F
Formula:	C20H23F3N2O2
M.Wt:	380.4040
Purity:	>98%
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:	MK-8998 is a potent and selective antagonist of the T-type calcium channel.
In Vivo:	MK-8998 is not effective in treating acutely psychotic inpatients with schizophrenia. There are no significant differences between either MK-8998 or olanzapine versus placebo at any time point. MK-8998 and olanzapine are generally well tolerated but are associated with a higher percentage of adverse events compared with placebo[1].
In Vitro:	MK-8998 is a potent and selective antagonist of the T-type calcium channel that is being investigated as a potential new therapy for the treatment of schizophrenia. Because MK-8998 does not block D2, 5HT2a, muscarinic, or histaminic receptors, it has the potential for a substantially improved side effect profile compared with currently available atypical antipsychotics[1].
References:	[1]. Egan MF, et al. Randomized controlled study of the T-type calcium channel antagonist MK-8998 for the treatment of acute psychosis in patients with schizophrenia. Hum Psychopharmacol. 2013 Mar;28(2):124-33.