ML 161(ML161)|PAR1 inhibitor|cas 423735-93-7|DC Chemicals|

Cas No.:	423735-93-7
Chemical Name:	2-Bromo-N-(3-butyramidophenyl)benzamide
Synonyms:	2-Bromo-N-(3-butyramidophenyl)benzamide;ML 161;2-bromo-N-[3-(butanoylamino)phenyl]benzamide;ML-161;2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]-benzamide;ML161;2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]benzamide;2-bromo-N-[3-(butyrylamino)phenyl]benzamide;AK142591;SMR000193713;MLS000571703;Cambridge id 5946339;Oprea1_852187;MLS002699906;ARONIS27179;AOB1565;DFOVLSMXPWPCFH-UHFFFAOYSA-N;HMS3651N10;BENZAMIDE, 2-BROMO-N-[3-[(1-OXOBUTYL)AMINO]PHENYL]-;HMS2461M06;BC;Parmodulin 2;2-bromo-N-[3-(1-oxobutylamino)phenyl]benzamide;BENZAMIDE, 2-BROMO-N-[3-[
SMILES:	BrC1=C([H])C([H])=C([H])C([H])=C1C(N([H])C1=C([H])C([H])=C([H])C(=C1[H])N([H])C(C([H])([H])C([H])([H])C([H])([H])[H])=O)=O
Formula:	C₁₇H₁₇BrN₂O₂
M.Wt:	361.2331
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Parmodulin 2 (ML161),a probe, is an allosteric inhibitor of protease-activated receptor 1 (PAR1) with an IC50 of 0.26 μM. Parmodulin 2 inhibits platelet aggregation induced by a PAR1 peptide agonist or by thrombin and has shown cytoprotective effects[1, 2].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC8860	Vorapaxar	Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM.
DC7197	ML 161	Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.
DC11923	BMS-986120	BMS-986120 (BMS986120) is a potent, selective, orally bioavailable, and reversible PAR4 antagonist with Kd of 0.098 nM for human PAR4.
DC10879	AZ3451	AZ3451 is a potent and selective allosteric antagonist of protease-activated receptor 2 (PAR2)