MRK003

Cas No.:	623165-93-5
Synonyms:	MRK 003,MRK-003
SMILES:	FC(F)(F)CN(C[C@]1(N2)[C@H]3CC4=C(C=CC(/C=C/CN5CCC(C(F)(F)F)CC5)=C4)C[C@@H]1CC3)S2(=O)=O
Formula:	C25H31F6N3O2S
M.Wt:	551.59
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Description of MRK003: MRK003 is a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma. MRK003 treatment induced caspase-dependent apoptosis and inhibited proliferation of MM and NHL cell lines and patient cells. Examination of signaling events after treatment showed time-dependent decrease in levels of the notch intracellular domain, Hes1 and c-Myc. MRK003 downregulated cyclin D1, Bcl-Xl and Xiap levels in NHL cells and p21, Bcl-2 and Bcl-Xl in MM cells. In addition, MRK003 caused an upregulation of pAkt, indicating crosstalk with the PI3K/Akt pathway. (source: Leukemia (2012) 26, 340–348; doi:10.1038/leu.2011.192). For the detailed information about the solubility of MRK003 in water, the solubility of MRK003 in DMSO, the solubility of MRK003 in PBS buffer, the animal experiment（test） of MRK003,the in vivo,in vitro and clinical trial test of MRK003,the cell experiment（test） of MRK003,the IC50, EC50 and Affinity of MRK003, please contact DC Chemicals.